GFC Life Sciences Publishes 'Research on Plant-Derived Skin Longevity Materials' in International Journal
GFC Life Sciences's research on the discovery of plant-derived skin longevity materials has been published in the international journal 'Antioxidants' (impact factor 8.2 as of 2025).
According to GFC Life Sciences on July 30, this study utilized a human dermal fibroblast aging model induced by oxidative stress to comparatively evaluate 20 types of plant extracts under identical conditions. The team systematically analyzed the correlations among phytochemical composition of the plant-derived materials, antioxidant activity, and senescent cell clearance efficacy.
The researchers established a standardized screening platform that incorporated total flavonoid analysis, UPLC-Q-TOF-MS-based phytochemical profiling, assessment of antioxidant activity, and evaluation of selective elimination efficacy for senescent cells. This enabled the development of an evaluation system capable of comparing different plant resources based on the same criteria.
The results showed that extracts from water lily, chlorella, green tea, and rosemary displayed outstanding senolytic activity by selectively inducing cell death in senescent cells while maintaining low toxicity to normal skin cells. Furthermore, the study confirmed that a high level of antioxidant activity or total flavonoid content does not necessarily equate to strong senolytic efficacy. The findings emphasized the importance of conducting both phytochemical profiling and cell-based phenotypic evaluation when discovering effective materials.
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GFC Life Sciences stated, “Upon conducting additional mechanism analysis on the water lily extract, which was selected as the lead material, the research team found that it inhibits the anti-apoptotic protein MCL-1 and reduces the expression of senescence-associated secretory phenotype factors such as MMP-1, MMP-3, IL-8, and CCL1.” They added, “These results indicate that water lily extract not only exerts a senolytic effect by clearing senescent cells but also has potential as a material that suppresses inflammatory secretions from senescent cells.”
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